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Publications

 

  1. Genome integrity as a potential index of longevity in Ashkenazi Centenarian's families. Andrawus M, David GB, Terziyska I, Sharvit L, Bergman A, Barzilai N, Raj SM, Govindaraju DR, Atzmon G. Geroscience. 2024 May 9. doi: 10.1007/s11357-024-01178-0. Online ahead of print.PMID: 38724875

  2. Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology. Miller B, Kim SJ, Cao K, Mehta HH, Thumaty N, Kumagai H, Iida T, McGill C, Pike CJ, Nurmakova K, Levine ZA, Sullivan PM, Yen K, Ertekin-Taner N, Atzmon G, Barzilai N, Cohen P.Aging Cell. 2024 Jul;23(7):e14153. doi: 10.1111/acel.14153. Epub 2024 Mar 22.PMID: 38520065 Free PMC article.

  3. Polygenic prediction of human longevity on the supposition of pervasive pleiotropy. Jabalameli MR, Lin JR, Zhang Q, Wang Z, Mitra J, Nguyen N, Gao T, Khusidman M, Atzmon G, Milman S, Vijg J, Barzilai N, Zhang ZD.medRxiv [Preprint]. 2023 Dec 11:2023.12.10.23299795. doi: 10.1101/2023.12.10.23299795.PMID: 38168353 Free PMC article. Preprint.

  4. A genomic mutational constraint map using variation in 76,156 human genomes. Chen S, Francioli LC, Goodrich JK, Collins RL, Kanai M, Wang Q, Alföldi J, Watts NA, Vittal C, Gauthier LD, Poterba T, Wilson MW, Tarasova Y, Phu W, Grant R, Yohannes MT, Koenig Z, Farjoun Y, Banks E, Donnelly S, Gabriel S, Gupta N, Ferriera S, Tolonen C, Novod S, Bergelson L, Roazen D, Ruano-Rubio V, Covarrubias M, Llanwarne C, Petrillo N, Wade G, Jeandet T, Munshi R, Tibbetts K; Genome Aggregation Database Consortium; O'Donnell-Luria A, Solomonson M, Seed C, Martin AR, Talkowski ME, Rehm HL, Daly MJ, Tiao G, Neale BM, MacArthur DG, Karczewski KJ.Nature. 2024 Jan;625(7993):92-100. doi: 10.1038/s41586-023-06045-0. Epub 2023 Dec 6.PMID: 38057664

  5.  Inferring compound heterozygosity from large-scale exome sequencing data. Guo MH, Francioli LC, Stenton SL, Goodrich JK, Watts NA, Singer-Berk M, Groopman E, Darnowsky PW, Solomonson M, Baxter S; gnomAD Project Consortium; Tiao G, Neale BM, Hirschhorn JN, Rehm HL, Daly MJ, O'Donnell-Luria A, Karczewski KJ, MacArthur DG, Samocha KE.Nat Genet. 2024 Jan;56(1):152-161. doi: 10.1038/s41588-023-01608-3. Epub 2023 Dec 6.PMID: 38057443 Free PMC article

  6. The Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism-A Favorable Backdoor Mechanism for the GHR Function. Falah G, Sharvit L, Atzmon G. Int J Mol Sci. 2023 Sep 10;24(18):13908. doi: 10.3390/ijms241813908.PMID: 37762211 Free PMC article. Review.

  7. Copy number variation as a tool for implementing pregnancy as an aging model. Andrawus M, Sharvit L, Touitou N, Lerrer B, Cohen HY, Atzmon G. Aging (Albany NY). 2023 Aug 28;15(16):7922-7932. doi: 10.18632/aging.204936. Epub 2023 Aug 28.PMID: 37639552 Free PMC article.

  8. Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians. Zhu Y, Ryu S, Tare A, Barzilai N, Atzmon G, Suh Y.Aging Cell. 2023 Oct;22(10):e13962. doi: 10.1111/acel.13962. Epub 2023 Aug 22.PMID: 37605876 Free PMC article. page 211

  9.  Quantification of bacterial adhesion to tissue in high-throughput kinetics. Shteindel N, Gutman D, Atzmon G, Gerchman Y.Biol Methods Protoc. 2023 Jul 26;8(1):bpad014. doi: 10.1093/biomethods/bpad014. eCollection 2023.PMID: 37576438 Free PMC article. 

  10. The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevity. Wang X, Jung HJ, Milholland B, Cui J, Tazearslan C, Atzmon G, Wang X, Yang J, Guo Q, Barzilai N, Robbins PD, Suh Y.bioRxiv [Preprint]. 2023 May 20:2023.05.19.541542. doi: 10.1101/2023.05.19.541542.PMID: 37292828 Free PMC article. Preprint

  11. Can Epigenetics Predict Drug Efficiency in Mental Disorders? Ben David G, Amir Y, Salalha R, Sharvit L, Richter-Levin G, Atzmon G. Cells. 2023 Apr 17;12(8):1173. doi: 10.3390/cells12081173.PMID: 37190082 Free PMC article. Review.

  12. Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity. Adwan Shekhidem H, Sharvit L, Huffman DM, Manov I, Atzmon G, Shams I.Genes (Basel). 2023 Mar 31;14(4):845. doi: 10.3390/genes14040845.PMID: 37107603 Free PMC article.

  13. Exposure to Juvenile Stress Induces Epigenetic Alterations in the GABAergic System in Rats. Ben David G, Amir Y, Tripathi K, Sharvit L, Benhos A, Anunu R, Richter-Levin G, Atzmon G. Genes (Basel). 2023 Feb 23;14(3):565. doi: 10.3390/genes14030565.PMID: 36980837

  14. Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome. Jain P, Miller-Fleming T, Topaloudi A, Yu D, Drineas P, Georgitsi M, Yang Z, Rizzo R, Müller-Vahl KR, Tumer Z, Mol Debes N, Hartmann A, Depienne C, Worbe Y, Mir P, Cath DC, Boomsma DI, Roessner V, Wolanczyk T, Janik P, Szejko N, Zekanowski C, Barta C, Nemoda Z, Tarnok Z, Buxbaum JD, Grice D, Glennon J, Stefansson H, Hengerer B, Benaroya-Milshtein N, Cardona F, Hedderly T, Heyman I, Huyser C, Morer A, Mueller N, Munchau A, Plessen KJ, Porcelli C, Walitza S, Schrag A, Martino D; Psychiatric Genomics Consortium Tourette Syndrome Working Group (PGC-TS); EMTICS collaborative group; Dietrich A; TS-EUROTRAIN Network; Mathews CA, Scharf JM, Hoekstra PJ, Davis LK, Paschou P.Transl Psychiatry. 2023 Feb 23;13(1):69. doi: 10.1038/s41398-023-02341-5.PMID: 36823209 Free PMC article.

  15. Dietary Walnuts Preserve Aspects of Health Span and Alter the Hippocampal Lipidome in Aged High-Fat Diet-Fed Mice. Novaj A, Engel MG, Wang R, Mao K, Xue X, Amir Y, Atzmon G, Huffman DM.Int J Mol Sci. 2023 Jan 24;24(3):2314. doi: 10.3390/ijms24032314.PMID: 36768636 Free PMC article.

  16. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V.EMBO J. 2023 Feb 1;42(3):e113326. doi: 10.15252/embj.2022113326.PMID: 36722290 Free PMC article.

  17. A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants. Bae H, Gurinovich A, Karagiannis TT, Song Z, Leshchyk A, Li M, Andersen SL, Arbeev K, Yashin A, Zmuda J, An P, Feitosa M, Giuliani C, Franceschi C, Garagnani P, Mengel-From J, Atzmon G, Barzilai N, Puca A, Schork NJ, Perls TT, Sebastiani P.Int J Mol Sci. 2022 Dec 21;24(1):116. doi: 10.3390/ijms24010116.PMID: 36613555 Free PMC article.

  18. Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century. Waldman S, Backenroth D, Harney É, Flohr S, Neff NC, Buckley GM, Fridman H, Akbari A, Rohland N, Mallick S, Olalde I, Cooper L, Lomes A, Lipson J, Cano Nistal J, Yu J, Barzilai N, Peter I, Atzmon G, et al. Cell. 2022 Dec 8;185(25):4703-4716.e16. doi: 10.1016/j.cell.2022.11.002. Epub 2022 Nov 30.PMID: 36455558 Free PMC article.

  19. Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event. Andrawus M, Sharvit L, Atzmon G. Int J Mol Sci. 2022 Oct 21;23(20):12698. doi: 10.3390/ijms232012698.PMID: 36293556 Free PMC article. Review.

  20. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Thomas DD, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V.EMBO J. 2022 Nov 2;41(21):e110393. doi: 10.15252/embj.2021110393. Epub 2022 Oct 10.PMID: 36215696 Free PMC article.

  21. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility. Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, Avila B, Abreu MT, Ahmad T, Allez M, Ananthakrishnan AN, Atzmon G, et al. Nat Genet. 2022 Sep;54(9):1275-1283. doi: 10.1038/s41588-022-01156-2. Epub 2022 Aug 29.PMID: 36038634 Free PMC article.

  22. High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity. Gonzalez B, Tare A, Ryu S, Johnson SC, Atzmon G, Barzilai N, Kaeberlein M, Suh Y.Geroscience. 2023 Feb;45(1):311-330. doi: 10.1007/s11357-022-00634-z. Epub 2022 Aug 10.PMID: 35948858 Free PMC article.

  23. Integrity of hypothalamic-pituitary-testicular axis in exceptional longevity. Aleksic S, Desai D, Ye K, Duran S, Gao T, Crandall J, Atzmon G, Barzilai N, Milman S.Aging Cell. 2022 Aug;21(8):e13656. doi: 10.1111/acel.13656. Epub 2022 Jun 29.PMID: 35770332 Free PMC article.

  24. Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. Hindy G, Dornbos P, Chaffin MD, Liu DJ, Wang M, Selvaraj MS, Zhang D, Park J, Aguilar-Salinas CA, Antonacci-Fulton L, Ardissino D, Arnett DK, Aslibekyan S, Atzmon G, et al. Am J Hum Genet. 2022 Jan 6;109(1):81-96. doi: 10.1016/j.ajhg.2021.11.021. Epub 2021 Dec 20.PMID: 34932938 Free PMC article.

  25. Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation. Longchamps RJ, Yang SY, Castellani CA, Shi W, Lane J, Grove ML, Bartz TM, Sarnowski C, Liu C, Burrows K, Guyatt AL, Gaunt TR, [....], Atzmon G, Ye K, Barzilai N, Brody JA, Psaty BM, Taylor KD, Rotter JI, Boerwinkle E, Pankratz N, Arking DE.Hum Genet. 2022 Jan;141(1):127-146. doi: 10.1007/s00439-021-02394-w. Epub 2021 Dec 2.PMID: 34859289 Free PMC article.

  26. Elevated common variant genetic risk for tourette syndrome in a densely-affected pedigree. Halvorsen M, Szatkiewicz J, Mudgal P, Yu D; Psychiatric Genomics Consortium TS/OCD Working Group; Nordsletten AE, Mataix-Cols D, Mathews CA, Scharf JM, Mattheisen M, Robertson MM, McQuillin A, Crowley JJ.Mol Psychiatry. 2021 Dec;26(12):7522-7529. doi: 10.1038/s41380-021-01277-w. Epub 2021 Sep 15.PMID: 34526668 Free PMC article.

  27. Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans. Gudmundsson S, Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alföldi J, Wang Q, Collins RL, Laricchia KM, Ganna A, Birnbaum DP, Gauthier LD, Brand H, Solomonson M, Watts NA, Rhodes D, Singer-Berk M, England EM, Seaby EG, Kosmicki JA, Walters RK, Tashman K, Farjoun Y, Banks E, Poterba T, Wang A, Seed C, Whiffin N, Chong JX, Samocha KE, Pierce-Hoffman E, Zappala Z, O'Donnell-Luria AH, Minikel EV, Weisburd B, Lek M, Ware JS, Vittal C, Armean IM, Bergelson L, Cibulskis K, Connolly KM, Covarrubias M, Donnelly S, Ferriera S, Gabriel S, Gentry J, Gupta N, Jeandet T, Kaplan D, Llanwarne C, Munshi R, Novod S, Petrillo N, Roazen D, Ruano-Rubio V, Saltzman A, Schleicher M, Soto J, Tibbetts K, Tolonen C, Wade G, Talkowski ME; Genome Aggregation Database Consortium; Neale BM, Daly MJ, MacArthur DG.Nature. 2021 Sep;597(7874):E3-E4. doi: 10.1038/s41586-021-03758-y.PMID: 34373650 Free PMC article. No abstract available.

  28. Genetic signature of human longevity in PKC and NF-κB signaling.Ryu S, Han J, Norden-Krichmar TM, Zhang Q, Lee S, Zhang Z, Atzmon G, Niedernhofer LJ, Robbins PD, Barzilai N, Schork NJ, Suh Y.Aging Cell. 2021 Jul;20(7):e13362. doi: 10.1111/acel.13362. Epub 2021 Jul 1.PMID: 34197020 Free PMC article.

  29. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, et al. Nat Commun. 2021 Jun 9;12(1):3505. doi: 10.1038/s41467-021-23556-4.PMID: 34108472 Free PMC article.

  30. Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes.Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, et al .Nat Commun. 2021 Apr 23;12(1):2463. doi: 10.1038/s41467-021-22613-2.PMID: 33893282 Free PMC article. No abstract available.

  31. Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia. Lencz T, Yu J, Khan RR, Flaherty E, Carmi S, Lam M, Ben-Avraham D, Barzilai N, Bressman S, Darvasi A, Cho JH, Clark LN, GümüÅŸ ZH, Vijai J, Klein RJ, Lipkin S, Offit K, Ostrer H, Ozelius LJ, Peter I, Malhotra AK, Maniatis T, Atzmon G, Pe'er I. Neuron. 2021 May 5;109(9):1465-1478.e4. doi: 10.1016/j.neuron.2021.03.004. Epub 2021 Mar 22.PMID: 33756103 Free PMC article.

  32. Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers. Fulton-Howard B, Goate AM, Adelson RP, Koppel J, Gordon ML; Alzheimer's Disease Genetics Consortium; Barzilai N, Atzmon G, Davies P, Freudenberg-Hua Y. Neurobiol Aging. 2021 Mar;99:101.e1-101.e9. doi: 10.1016/j.neurobiolaging.2020.09.014. Epub 2020 Sep 30.PMID: 33164815 Free PMC article.

  33. Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. Gutman D, Lidzbarsky G, Milman S, Gao T, Sin-Chan P, Gonzaga-Jauregui C; Regeneron Genetics Center; Deelen J, Shuldiner AR, Barzilai N, Atzmon G. Aging Cell. 2020 Oct;19(10):e13216. doi: 10.1111/acel.13216. Epub 2020 Aug 29.PMID: 32860726 Free PMC article.

  34. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. Aging (Albany NY). 2020 Jun 23;12(12):11185-11199. doi: 10.18632/aging.103534. Epub 2020 Jun 23.PMID: 32575074 Free PMC article.

  35. Giller A, Andrawus M, Gutman D, Atzmon G. PREGNANCY AS A MODEL FOR AGING. Ageing Res Rev. 2020 Jun 2:101093. doi: 10.1016/j.arr.2020.101093. Epub ahead of print. PMID: 32502628.

  36. Whiffin N, Armean IM, Kleinman A, Marshall JL, Minikel EV, Goodrich JK, Quaife NM, Cole JB, Wang Q, Karczewski KJ, Cummings BB, Francioli L, Laricchia K, Guan A, Alipanahi B, Morrison P, Baptista MAS, Merchant KM; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Ware JS, Havulinna AS, Iliadou B, Lee JJ, Nadkarni GN, Whiteman C; 23andMe Research Team, Daly M, Esko T, Hultman C, Loos RJF, Milani L, Palotie A, Pato C, Pato M, Saleheen D, Sullivan PF, Alföldi J, Cannon P, MacArthur DG. The effect of LRRK2 loss-of-function variants in humans. Nat Med. 2020 May 27. doi: 10.1038/s41591-020-0893-5. Epub ahead of print. PMID: 32461697. 

  37. Cummings BB, Karczewski KJ, Kosmicki JA, Seaby EG, Watts NA, Singer-Berk M, Mudge JM, Karjalainen J, Satterstrom FK, O'Donnell-Luria AH, Poterba T, Seed C, Solomonson M, Alföldi J; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Daly MJ, MacArthur DG. Transcript expression-aware annotation improves rare variant interpretation. Nature. 2020 May;581(7809):452-458. doi: 10.1038/s41586-020-2329-2. Epub 2020 May 27. PMID: 32461655.

  38. Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alföldi J, Wang Q, Collins RL, Laricchia KM, Ganna A, Birnbaum DP, Gauthier LD, Brand H, Solomonson M, Watts NA, Rhodes D, Singer-Berk M, England EM, Seaby EG, Kosmicki JA, Walters RK, Tashman K, Farjoun Y, Banks E, Poterba T, Wang A, Seed C, Whiffin N, Chong JX, Samocha KE, Pierce-Hoffman E, Zappala Z, O'Donnell-Luria AH, Minikel EV, Weisburd B, Lek M, Ware JS, Vittal C, Armean IM, Bergelson L, Cibulskis K, Connolly KM, Covarrubias M, Donnelly S, Ferriera S, Gabriel S, Gentry J, Gupta N, Jeandet T, Kaplan D, Llanwarne C, Munshi R, Novod S, Petrillo N, Roazen D, Ruano-Rubio V, Saltzman A, Schleicher M, Soto J, Tibbetts K, Tolonen C, Wade G, Talkowski ME; Genome Aggregation Database Consortium, Neale BM, Daly MJ, MacArthur DG. The mutational constraint spectrum quantified from variation in 141,456 humans. Nature. 2020 May;581(7809):434-443. doi: 10.1038/s41586-020-2308-7. Epub 2020 May 27. PMID: 32461654.

  39. Minikel EV, Karczewski KJ, Martin HC, Cummings BB, Whiffin N, Rhodes D, Alföldi J, Trembath RC, van Heel DA, Daly MJ; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Schreiber SL, MacArthur DG. Evaluating drug targets through human loss-of-function genetic variation. Nature. 2020 May;581(7809):459-464. doi: 10.1038/s41586-020-2267-z. Epub 2020 May 27. PMID: 32461653.

  40. Collins RL, Brand H, Karczewski KJ, Zhao X, Alföldi J, Francioli LC, Khera AV, Lowther C, Gauthier LD, Wang H, Watts NA, Solomonson M, O'Donnell-Luria A, Baumann A, Munshi R, Walker M, Whelan CW, Huang Y, Brookings T, Sharpe T, Stone MR, Valkanas E, Fu J, Tiao G, Laricchia KM, Ruano-Rubio V, Stevens C, Gupta N, Cusick C, Margolin L; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Taylor KD, Lin HJ, Rich SS, Post WS, Chen YI, Rotter JI, Nusbaum C, Philippakis A, Lander E, Gabriel S, Neale BM, Kathiresan S, Daly MJ, Banks E, MacArthur DG, Talkowski ME. A structural variation reference for medical and population genetics. Nature. 2020 May;581(7809):444-451. doi: 10.1038/s41586-020-2287-8. Epub 2020 May 27. PMID:32461652.

  41. Whiffin N, Karczewski KJ, Zhang X, Chothani S, Smith MJ, Evans DG, Roberts AM, Quaife NM, Schafer S, Rackham O, Alföldi J, O'Donnell-Luria AH, Francioli LC; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Cook SA, Barton PJR, MacArthur DG, Ware JS. Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals. Nat Commun. 2020 May 27;11(1):2523. doi: 10.1038/s41467-019-10717-9. PMID: 32461616.

  42. Wang Q, Pierce-Hoffman E, Cummings BB, Alföldi J, Francioli LC, Gauthier LD, Hill AJ, O'Donnell-Luria AH; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Karczewski KJ, MacArthur DG. Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes. Nat Commun. 2020 May 27;11(1):2539. doi: 10.1038/s41467-019-12438-5. PMID: 32461613.

  43. Amir Y, Insler M, Giller A, Gutman D, Atzmon G. Senescence and Longevity of Sea Urchins. Genes (Basel). 2020 May 20;11(5):E573. doi: 10.3390/genes11050573. PMID: 32443861. 

  44. Andrawus M, Sharvit L, Shekhidem HA, Roichman A, Cohen HY, Atzmon G. The effects of environmental stressors on candidate aging associated genes. Exp Gerontol. 2020 Apr 25;137:110952. doi: 10.1016/j.exger.2020 .110952. Epub ahead of print. PMID: 32344118.

  45. Rozanov L, Ravichandran M, Grigolon G, Zanellati MC, Mansfeld J, Zarse K, Barzilai N, Atzmon G, Fischer F, Ristow M. Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A. Redox Biol. 2020 May;32:101448. doi: 10.1016/j.redox.2020.101448. Epub 2020 Feb 4. PMID: 32203922; PMCID: PMC7096751. 

  46. Falah G, Giller A, Gutman D, Atzmon G. Breaking the Glass Ceiling. Gerontology. 2020 Feb 26:1-6. doi: 10.1159/000505995. Epub ahead of print. PMID: 32101855.

  47. Gutman D, Rivkin E, Fadida A, Sharvit L, Hermush V, Rubin E, Kirshner D, Sabin I, Dwolatzky T, Atzmon G. Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity. Int J Mol Sci. 2020 Jan 17;21(2):615. doi: 10.3390/ijms21020615. PMID: 31963520; PMCID: PMC7013521.

  48. Karavani E, Zuk O, Zeevi D, Barzilai N, Stefanis NC, Hatzimanolis A, Smyrnis N, Avramopoulos D, Kruglyak L, Atzmon G, Lam M, Lencz T, Carmi S. Screening Human Embryos for Polygenic Traits Has Limited Utility. Cell. 2019 Nov 27;179(6):1424-1435.e8. doi: 10.1016/j.cell.2019.10.033. Epub 2019 Nov 21. PMID: 31761530; PMCID: PMC6957074.

  49. Gurinovich A, Andersen SL, Puca A, Atzmon G, Barzilai N, Sebastiani P. Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities. J Gerontol A Biol Sci Med Sci. 2019 Nov 13;74(Supplement_1):S45-S51. doi: 10.1093/gerona/glz179. PMID: 31724059.

  50. Adelson RP, Renton AE, Li W, Barzilai N, Atzmon G, Goate AM, Davies P, Freudenberg-Hua Y. Empirical design of a variant quality control pipeline for whole genome sequencing data using replicate discordance. Sci Rep. 2019 Nov 6;9(1):16156. doi: 10.1038/s41598-019-52614-7. PMID: 31695094; PMCID: PMC6834861.

  51. Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019 Aug 14;10(1):3669. doi: 10.1038/s41467-019-11558-2. PMID: 31413261; PMCID: PMC6694136.

  52. Adwan Shekhidem H, Sharvit L, Leman E, Manov I, Roichman A, Holtze S, M Huffman D, Y Cohen H, Bernd Hildebrandt T, Shams I, Atzmon G. Telomeres and Longevity: A Cause or an Effect? Int J Mol Sci. 2019 Jul 1;20(13):3233. doi: 10.3390/ijms20133233. PMID: 31266154; PMCID: PMC6651551.

  53. Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-[.....], Atzmon G, et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 Jun;570(7759):71-76. doi: 10.1038/s41586-019-1231-2. Epub 2019 May 22. PMID: 31118516; PMCID: PMC6699738.

  54. Yu D, Sul JH, Tsetsos F, Nawaz MS, Huang AY, Zelaya I, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, [.....], Atzmon G, Barzilai N, Wagner M, Moessner R, Ophoff R, Pato CN, Pato MT, Knowles JA, Roffman JL, Smoller JW, Buckner RL, Willsey AJ, Tischfield JA, Heiman GA, Stefansson H, Stefansson K, Posthuma D, Cox NJ, Pauls DL, Freimer NB, Neale BM, Davis LK, Paschou P, Coppola G, Mathews CA, Scharf JM; Tourette Association of America International Consortium for Genetics, the Gilles de la Tourette GWAS Replication Initiative, the Tourette International Collaborative Genetics Study, and the Psychiatric Genomics Consortium Tourette Syndrome Working Group. Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies. Am J Psychiatry. 2019 Mar 1;176(3):217-227. doi: 10.1176/appi.ajp.2018.18070857. PubMed PMID: 30818990.

  55. Gurinovich A, Bae H, Farrell JJ, Andersen SL, Monti S, Puca A, Atzmon G, Barzilai N, Perls TT, Sebastiani P. PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects. Bioinformatics. 2019 Jan 8. doi: 10.1093/bioinformatics/btz017. [Epub ahead of print] PubMed PMID: 30624692.

  56. Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. APOE Alleles and Extreme Human Longevity. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):44-51. doi: 10.1093/gerona/gly174. PubMed PMID: 30060062; PubMed Central PMCID: PMC6298189.

  57. Gielen M, Hageman GJ, Antoniou EE, Nordfjall K, Mangino M, Balasubramanyam M, de Meyer T, Hendricks AE, Giltay EJ, Hunt SC, Nettleton JA, Salpea KD, Diaz VA, Farzaneh-Far R, Atzmon G, et al. Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies. Am J Clin Nutr. 2018 Sep 1;108(3):453-475. doi: 10.1093/ajcn/nqy107. PubMed PMID: 30535086; PubMed Central PMCID: PMC6454526.

  58. Udler MS, Kim J, von Grotthuss M, Bonàs-Guarch S, Cole JB, Chiou J; Christopher D. Anderson on behalf of METASTROKE and the ISGC, Boehnke M, Laakso M, Atzmon G, Glaser B, Mercader JM, Gaulton K, Flannick J, Getz G, Florez JC. Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis. PLoS Med. 2018 Sep 21;15(9):e1002654. doi: 10.1371/journal.pmed.1002654. eCollection 2018 Sep. PubMed PMID: 30240442; PubMed Central PMCID: PMC6150463.

  59. Lidzbarsky G, Gutman D, Shekhidem HA, Sharvit L, Atzmon G. Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes. Front Med (Lausanne). 2018 Apr 17;5:104. doi: 10.3389/fmed.2018.00104. eCollection 2018. Review. PubMed PMID: 29719834; PubMed Central PMCID: PMC5913290.

  60. Sathyan S, Barzilai N, Atzmon G, Milman S, Ayers E, Verghese J. Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty. Front Med (Lausanne). 2018 May 1;5:105. doi: 10.3389/fmed.2018.00105. eCollection 2018. PubMed PMID: 29765957; PubMed Central PMCID: PMC5938407.

  61. Lencz T, Yu J, Palmer C, Carmi S, Ben-Avraham D, Barzilai N, Bressman S, Darvasi A, Cho JH, Clark LN, GümüÅŸ ZH, Joseph V, Klein R, Lipkin S, Offit K, Ostrer H, Ozelius LJ, Peter I, Atzmon G, Pe'er I. High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation. Hum Genet. 2018 Apr;137(4):343-355. doi: 10.1007/s00439-018-1886-z. Epub 2018 Apr 28. PubMed PMID: 29705978.

  62. Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, et al. Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genet. 2018 May 24;14(5):e1007329. doi: 10.1371/journal.pgen.1007329. eCollection 2018 May. PubMed PMID: 29795570; PubMed Central PMCID: PMC5967709.

  63. Hui KY, Fernandez-Hernandez H, Hu J, Schaffner A, Pankratz N, Hsu NY, Chuang LS, Carmi S, Villaverde N, Li X, Rivas M, Levine AP, Bao X, Labrias PR, Haritunians T, Ruane D, Gettler K, Chen E, Li D, Schiff ER, Pontikos N, Barzilai N, Brant SR, Bressman S, Cheifetz AS, Clark LN, Daly MJ, Desnick RJ, Duerr RH, Katz S, Lencz T, Myers RH, Ostrer H, Ozelius L, Payami H, Peter Y, Rioux JD, Segal AW, Scott WK, Silverberg MS, Vance JM, Ubarretxena-Belandia I, Foroud T, Atzmon G, Pe'er I, Ioannou Y, McGovern DPB, Yue Z, Schadt EE, Cho JH, Peter I. Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med. 2018 Jan 10;10(423). pii: eaai7795. doi: 10.1126/scitranslmed.aai7795. PubMed PMID: 29321258; PubMed Central PMCID: PMC6028002.

  64. Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, [....], Atzmon G, Below JE, Dupuis J, Nicolae DL, Lehman D, Park T, Won S, Sladek R, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Abecasis GR, Blangero J. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):379-384. doi: 10.1073/pnas.1705859115. Epub 2017 Dec 26. PubMed PMID: 29279374; PubMed Central PMCID: PMC5777025.

  65. Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ,Caulkins L, Koesterer R, Ma C, Moutsianas L, [.....}, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data. 2017 Dec 19;4:170179. doi: 10.1038/sdata.2017.179. Erratum in: Sci Data. 2018 Jan 23;5:180002. PubMed PMID: 29257133; PubMed Central PMCID:  PMC5735917.

  66. Hwang JL, Park SY, Ye H, Sanyoura M, Pastore AN, Carmody D, Del Gaudio D,Wilson JF, Hanis CL, Liu X, Atzmon G, Glaser B, Philipson LH, Greeley SAW; T2D-Genes Consortium. FOXP3 mutations causing early-onset insulin-requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Pediatr Diabetes. 2018 May;19(3):388-392. doi: 10.1111/pedi.12612. Epub 2017 Nov 29. PubMed PMID: 29193502; PubMed Central PMCID: PMC5918222.

  67. Gubbi S, Schwartz E, Crandall J, Verghese J, Holtzer R, Atzmon G, Braunstein R, Barzilai N, Milman S. Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring. AJC 2017.

  68. Ben-Avraham D, Govindaraju DR, Budagov T, Fradin D, Durda P, Liu B, Ott S, Gutman D, Sharvit L, Kaplan R, Bougnères P, Reiner A, Shuldiner AR, Cohen P, Barzilai N, Atzmon G. The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Sci Adv. 2017 3(6):e1602025.

  69. Raz Y, Guerrero-Ros I, Maier A, Slagboom E, Atzmon G, Barzilai N, Macian F. Activation-induced autophagy is preserved in CD4+ T-cells in familial longevity. J. Gerontology Biological Sciences. 72(9):1201-1206, 2017.

  70. Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben Avraham D, Barzilai N, Puca A, Perls TT. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants. J. Gerontology Biological Sciences, 2017.

  71. Bae H. Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P, Effects of FOXO3 polymorphisms on survival to extreme longevity in four centenarian studies. J Gerontol A Biol Sci Med Sci 2017.

  72. Sathyan S, Barzilai N, Atzmon G, Milman S, Ayers E, Verghese J. Association of anti-inflammatory cytokine IL10 polymorphisms with Motoric Cognitive Risk syndrome in an Ashkenazi Jewish Population. Neurobiology of Aging. 58:238.e1–e8, 2017.

  73. Ben-Avraham D, Karasik D , Verghese J, Lunetta KL, Smith JA , Eicher JA, Vered R, Deelen J , Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R , Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SLR , Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G , Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G. The complex genetics of gait speed: genome-wide meta-analysis approach. Aging, 2017.

  74. Roshandel D, Klein R, Klein BE, Wolffenbuttel BH, van der Klauw MM, van Vliet-Ostaptchouk JV, Atzmon G, Ben-Avraham D, Crandall JP, Barzilai N, Bull SB, Canty AJ, Hosseini SM, Hiraki LT, Maynard J, Sell DR, Monnier VM, Cleary PA, Braffett BH; DCCT/EDIC Research Group., Paterson AD. New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins. Diabetes. 2016 Jul;65(7):2060-71.

  75. Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A; BIOS Consortium., Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, et al. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet, 48. 1462–1472 2016.

  76. Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T,  Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D,  Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R,  Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K,   Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan  S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise  AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH.  A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. Gastroenterology. 2016 151(4):710-723.

  77. Waldman YY, Biddanda A, Dubrovsky M, Campbell CL, Oddoux C, Friedman E, Atzmon G, Halperin E, Ostrer H, Keinan A. The genetic history of Cochin Jews from India. Hum Genet. 2016;135(10):1127-43.

  78. Freudenberg-Hua Y, Li W, Abhyankar A, Vacic V, Cortes V, Ben-Avraham D, Koppel J, Greenwald B, Germer S, T2D-GENES Consortium, Darnell RB, Barzilai N, Freudenberg J, Atzmon G, Davies P. Differential Burden of Rare Protein Truncating Variants in Alzheimer’s Disease Patients Compared to Centenarians. Human Molecular Genetics, 2016.

  79. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, […272 co-  authors…], Atzmon G, et al. The genetic  architecture  of  type  2 diabetes. Nature 2016.

  80. Marzec M, Hawkes CP, Eletto D, Boyle S, Rosenfeld R, Hwa V, Wit JM, van Duyvenvoorde HA, Oostdijk W, Losekoot M, Pedersen OB, Have CT, Yeap BB, Flicker L, Barzilai N, Atzmon G, Grimberg A, Argon Y. A human variant of Glucose-regulated protein 94 that inefficiently supports IGF production. Endocrinology 2016.

  81. Waldman YY, Biddanda A, Davidson NR, Billing-Ross P, Dubrovsky M, Campbell CL, Oddoux C, Friedman E, Atzmon G, Halperin E, Ostrer H, Keinan A. The genetics of Bene Israel from India reveals both substantial Jewish and Indian ancestry. PLoS One 2016.

  82. Ryu S, Atzmon G, Barzilai N, Raghavachari N, Suh Y. Genetic landscape of APOE in human longevity revealed by highthroughput sequencing. Mechanisms of Ageing and Development, 2016.

  83. Matteini AM, Tanaka T, Karasik D, Atzmon G, et al. GWAS Analysis of Hand Grip and Lower Body Strength in Older Adults in the CHARGE Consortium. Aging cell, 2016.

  84. Horikoshi M, Pasquali L, Wiltshire S, Huyghe JR, Mahajan A, Asimit JL, Ferreira T, Locke AE, Robertson NR, Wang X, Sim X, Fujita H, Hara K, Young R, Zhang W, Choi S, Chen H, Kaur I, Takeuchi F, Fontanillas P, Thuillier D, Yengo L, Below JE, Tam CHT, Wu Y, T2D-GENES Consortium, Abecasis G, Altshuler D, Bell GI, Blangero J, Burtt NP, Duggirala R, Florez JC, Hanis CL, Seielstad M, Atzmon G, Chan JCN, Ma RCW, Froguel P, Wilson JG, Bharadwaj D, Dupuis J, Meigs JB, Cho YS, Park T, Kooner JS, Chambers JC, Saleheen D, Kadowaki T, Tai ES, Mohlke KL, Cox NJ, Ferrer J, Zeggini E, Kato N, Teo YY, Boehnke M, McCarthy MI, Morris AP. diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics, 2016.

  85. Fortney K, Dobriban E, Garagnani P, Pirazzini C, Monti D, Mari D, Atzmon G, Barzilai N, Franceschi C, Owen AB, Kim SK. Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human                 Longevity. PLoS Genet. 2015 Dec 17; 11(12):e1005728

  86. Baskovich B, Hiraki S, Upadhyay K, Meyer P, Carmi S, Barzilai N, Darvasi A, Ozelius L, Peter I, Cho JH, Atzmon G, Clark L, Yu J, Lencz T, Pe'er I, Ostrer H, Oddoux C. Expanded genetic screening panel for the Ashkenazi                 Jewish population. Genet Med. 2015

  87. Deluty JA, Atzmon G, Crandall J, Barzilai N, Milman Sofiya. The influence of gender on inheritance of exceptional longevity. Aging, 7(6), 2015.

  88. Kato K, Zweig R, Schechter CB, Barzilai Nir, Atzmon G. Positive attitude toward life, emotional expression, self-rated health, and depressive symptoms among centenarians and near-centenarians. Aging & Mental Health, 2015.

  89. Govindaraju D, Atzmon G, Barzilai N. Genetics, lifestyle and longevity: Lessons from centenarians. Applied & Translational Genomics, 4, 23-32, 2015.

  90. Augustine TA, Baig M, Sood A, Budagov T, Atzmon G, Mariadason JM, Aparo S, Maitra R, Goel S. Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer. BJC, 112(2): 313-318, 2015.

  91. Han J, Atzmon G, Barzilai N, Suh Y. Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews. Translational Research, 65 (4), 480-481, 2015.

  92. Gutman D, Sharvit L and Atzmon G. Possible Mechanisms for Telomere Length Maintenance in Extremely Old People. Hereditary Genet, 3, e11, 2014.

  93. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI. on behalf of T2D-GENES; Boehnke M. on behalf of GoT2D; Altshuler D. on behalf of SIGMA T2D, Tuomileheto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL. Age-related clonal hematopoiesis associated with adverse outcomes. NEJM, 371 (26), 2488-2498, 2014.

  94. Gershoni M, Toiw Y, Ovadia O, Levin L, Shani N, Dadon S, Atzmon G, Wainstein J, Tsur A, Nijtmans L, Glaser B, Mishmar D. Interfering with nucleus-mitochondrial co-evolution disrupts OXPHOS complex I integrity and alters risk to type 2 diabetes mellitus. GBE, 6(10):2665-80, 2014.

  95. Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB; GoT2D Consortium; NHGRI JHS/FHS Allelic Spectrum Project; SIGMA T2D Consortium; T2D-GENES Consortium, Rosen ED, Altshuler D; GoT2D Consortium. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. PNAS. 111(36):13127-32, 2014.

  96. Zidan J, Ben-Avraham D, Carmi S, Maray  T, Friedman E, Atzmon G. Genotyping of geographically diverse Druze trios reveals substructure and a recent bottleneck. EJHG, 2014.

  97. Carmi S, Hui KY, Kochav E, Liu X, [….] Ostrer H, Atzmon G, Clark LN, Lencz T, Pe’er I. Whole genome sequencing of an Ashkenazi Jewish reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Nature Communication. 5:4835, 2014.

  98. Eny KM, Lutgers HL, Maynard J, Klein B, Lee KE, Atzmon G, Monnier VM, van Vliet – Ostaptchouk JV, Graaff R, van der Harst P, Snieder H, van der Klauw MM, Sell DR, Hosseini MS, Cleary PA, Braffett BH, Orchard TJ, Lyons TJ, Howard K, Klein R, Crandall JP, Barzilai N, Milman S, Ben-Avraham D, LifeLines Cohort Study, DCCT/EDIC Research Group, Wolffenbuttel BHR, Paterson AD. GWAS identifies the N-acetyltransferase 2 (NAT2) acetylator status tag SNP to be a major locus for skin fluorescence. Diabetologia. 57(8):1623-34, 2014.

  99. Freudenberg-Hua Y, Freudenberg J, Vacic V, Abhyankar A, Emde AK, Ben-Avraham D, Barzilai N, Oschwald D, Christen E, Koppel J, Greenwald B, Darnell RB, Germer S, Atzmon G, Davies P. Disease Variants in Genomes of 44 Centenarians. MGGM, 2(5):438-50, 2014.

  100. Friedman E, Moran DS, Ben-Avraham D, Yanovich R, Atzmon G. Novel candidate genes putatively involved in stress fracture predisposition detected by whole Exome sequencing. Genetics Research, 96:e004, 2014.

  101. Vacic V, Ozelius LJ, Clark LN, Bar-Shira A,  Gana-Weisz M, Gurevich T, Gusev A, Kedmi M, Kenny EE, Liu X, Mejia-Santana H, Mirelman A, Raymond D, Saunders-Pullman R, Desnick RJ, Atzmon G, Burns ER, Ostrer H, Hakonarson H, Bergman A, Barzilai N, Darvasi A, Peter I, Guha S, Lencz T, Giladi N, Marder K,  Pe’er I, Bressman SB, Orr-Urtreger A. Genome-wide mapping of identical-by-descent segments in an Ashkenazi Parkinson disease cohort identifies associated haplotypes. Human Molecular Genetics. 23(17):4693-702, 2014.

  102. Bashiri A, Heo HJ, Mazor M, Budagov T, Einstein FH,  Atzmon G. Pregnancy Complicated by Obesity Induces Global Dysregulation in Visceral and Subcutaneous Fat. Molecular Genetics and Genomics. 289(4):695-705, 2014.

  103. Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. Low Insulin-like Growth Factor-1 Level Predicts Survival in Humans with Exceptional Longevity. Aging Cell, 13(4):769-71, 2014.

  104. Flannick J, Thorleifsson G, Beer NL, Jacobs SBR, Grarup N, Mahajan A, Fuchsberger C, Atzmon G, et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nature genetics, 46(4):357-63, 2014.

  105. Atzmon G, Chang ALS, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N. Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study. Journal of Investigative Dermatology, 134(3):651-7, 2014.

  106. Milman S, Schulder-Katz M, Deluty J, Zimmerman ME, Crandall JP, Barzilai N, Melamed ML, Atzmon G. Individuals with Exceptional Longevity Manifest a Delayed Association between Vitamin D Insufficiency and Cognitive Impairment. J Am Geriatr Soc. 62(1):153-8, 2014.

  107. The SIGMA Type 2 Diabetes Consortium; Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C [….]; T2D-GENES Consortium, Flannick J, Fontanillas P, Morris A, Teslovich TM, Burtt NP, Atzmon G, et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature, 506(7486):97-101, 2014.

  108. Barzilai N, Atzmon G. Annual Review of Gerontology and Geriatrics, 34 (1): 171-188, 2014.

  109. Milman S, Atzmon G, Crandall J, Barzilai N. Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity. Curr Vasc Pharmacol. 12(5):690-7, 2014.

  110. Botigué LR, Henn BM, Gravel S, Maples BK, Gignoux CR, Corona E, Atzmon G, Burns E, Ostrer H, Flores C, Bertranpetit J, Comas D, Bustamante CD. Gene flow from North Africa contributes to differential human genetic diversity in southern Europe. PNAS, 110(29):11791-6, 2013.

  111. Kato K, Zweig R, Schechter CB, Verghese J, Barzilai N, Atzmon G. Personality, Self-Rated Health, and Cognition in Centenarians: Do Personality and Self-Rated Health Relate to Cognitive Function in Advanced Age?. Aging, 5(3):183-91, 2013.

  112. Axelrad MD, Atzmon G. Epigenomic of Aging. Hereditary Genetics, 2013.

  113. Axelrad MD, Budagov T, Atzmon G. Telomere length and telomerase activity; a yin and yang of cell senescence. J Vis Exp, (75). 2013.

  114. Wan J, Atzmon G, Hwang D, Barzlai N, Kratzsch J, Cohen P. Growth Hormone Receptor (GHR) Exon 3 Polymorphism Status Detection by Dual-Enzyme-Linked Immunosorbent Assay (ELISA). JCEM, 98(1): E77-E81, 2013.

  115. Han J, Ryu S, Moskowitz DM, Rothenberg D, Leahy DJ, Atzmon G, Barzilai N, Suh Y. Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. Mechanisms of Ageing and Dev. 134(10):478-85, 2013.

  116. Huffman DM, Augenlicht LH. , Zhang X, Lofrese JJ, Atzmon G, Chamberl JP. Mantzoros CS. Abdominal obesity, independently from caloric intake, accounts for the development of intestinal tumors in Apc1638N/+ female mice. Cancer Prevention Research, 6(3):177-87, 2013.

  117. Mirina A, Atzmon G, Ye K, Bergman A. Gene Size Matters. PLoS One, 7(11):e49093, 2012.

  118. Ben-Avraham D, Muzumdar RH, Atzmon G. Epigenetic-genome wide association (EWAS) methylation in aging and longevity. Epigenomics, 4(5):503-9, 2012.

  119. Gombar S, Jung HJ, Dong F, Calder B, Atzmon G, Barzilai N, Tian XL, Pothof J, Hoeijmakers JHJ, Campisi J, Vijg J, Suh Y. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC genomics, 13(1):353, 2012.

  120. Campbell CL, Palamara PF, Dubrovsky M, Botigué LR, Fellous M, Atzmon G, Oddoux C, Pearlman A, Hao L, Henn BM, Burns E, Bustamante CD, Comas D, Friedman E, Pe'er I, Ostrer H. North African Jewish and non-Jewish populations form distinctive, orthogonal clusters. PNAS, 109(34):13865-70, 2012.  

  121. Kato K, Zweig R, Barzilai N, Atzmon G. Positive Attitude Towards Life and Emotional Expression as Personality Phenotypes for Centenarians. Aging, 4(5):359-67, 2012.

  122. Broer L, Demerath EW, Garcia ME, Homuth G, Kaplan RC, Lunetta KL, Tanaka T, Tranah GJ, Walter S, Arnold AM, Atzmon G, et al. Association of heat shock proteins with all-cause mortality. Age (Dordr). 35(4):1367-76, 2012.

  123. Huffman DM, Deelen J, Ye K, Bergman A, Slagboom EP, Barzilai N, Atzmon G. Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: The case of the MTP gene. J Gerontol A Biol Sci Med Sci. 67(11):1153-60, 2012.

  124. Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell, 11(3):475-81, 2012.

  125. Atzmon G, Lai JYC, Melamed ML, Hostetter TH, Crandall JP, Barzilai N, Bitzer M. Family History of Exceptional Longevity is associated with lower serum uric acid levels. JAGS, 60(4):745-50, 2012. 

  126. Kenny EE, Pe’er I, Karban A, Ozelius L, Mitchell AA, Meng Ng S, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, et al. A Genome-Wide Scan of Ashkenazi Jewish Crohn’s Disease Suggests Novel Susceptibility Loci. PLoS Genetics, 8(3):e1002559, 2012.

  127. Tabatabaie V, Atzmon G, Rajpathak SN, Freeman R, Barzilai N, Crandall J. Exceptional longevity is associated with decreased reproduction. Aging, 3(12):1202-5, 2011.

  128. Hansen BC, Shamekh R, Budagov T, Linden E, Pessin J,  Atzmon G. The rhesus monkey: a nonhuman primate model for T2DM associated gene screening. J Diabetes Metab, 2:150. 2011.  

  129. Velez C, Palamara PF, Guevara-Aguirre J, Hao L, Karafet T, Guevara-Aguirre M, Pearlman A, Oddoux C, Hammer M, Burns E, Pe'er I, Atzmon G, Ostrer H. The Impact of Converso Jews on the Genomes of Modern Latin Americans. Human genetics, 131(2):251-63, 2012.

  130. Cai G, Atzmon G, Naj A, Beecham GW, Barzilai N, Haines JL, Sano M, Pericak-Vance M, Buxbaum JD. Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer Disease. Neurobiology of Aging, 33(2):416-417.e3, 2012.

  131. Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, et al. A Genome-Wide Association Study of Ageing. Neurobiology of Aging, 32(11): 2109.e15-e28, 2011.

  132. Rajpathak SN, Liu J, Ben-David O, Reddy S, Atzmon G, Crandall J, Barzilai N. Lifestyle Factors among People with Exceptional longevity. JAGS, 59(8):1509-12, 2011.

  133. Moorjani P, Patterson N, Hirschhorn JN, Hao L, Atzmon G, Burns E, Keinan A, Osterer H, Price A, Reich D. The history of African gene flow into Southern Europeans, Levantines and Jews. PLoS Genet 7(4): e1001373, 2011.

  134. Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D and Bergman A. The promise of human genetics in preventing ageing-related disease. JCEM, 95(10):4493-500. Erratum in: JCEM. 2011;96(6):1908, 2010.

  135. Muzumdar RH, Huffman DM, Calvert JW, Jha S, Weinberg Y, Cui L, Nemkal A, Atzmon G, Gundewar S, Yong Ji S, Lefer DJ. Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice. ATVB. 30(10):1940-8, 2010.

  136. Einstein FH, Huffman DM, Fishman S, Jerschow E, Heo HJ, Atzmon G, Barzilai N, Muzumdar RH. Aging per se Increases the Susceptibility to Free Fatty Acid-Induced Insulin Resistance. J Gerontol A Biol Sci Med Sci. 65(8):800-8, 2010.

  137. Thompson RF, Atzmon G, Liang HQ, Lowes C, Greally JM, Barzilai N. Tissue-specific dysregulation of DNA methylation in aging. Aging cell, 9(4):506-18, 2010.

  138. Atzmon G, Hao L,  Pe'er I, Velez C, Pearlman A, Palamara P, Morrow B, Friedman E, Oddoux C, Burns E, Ostrer H. Abraham’s Children in the Genome Era: Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry. AJHG, 86(6):850–9, 2010.

  139. Schechter CB, Barzilai N, Crandall JP, Atzmon G. Reduced Cholesteryl Ester Transfer Protein Levels Is Associated with Decreased Blood Pressure. Mayo Clinic Proceeding, 85(6):522-6, 2010.

  140. Neuman RJ, Wasson J, Atzmon G, Sun L, Barzilai N, Blech I, Glaser B, Permutt MA. Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in Genetically Homogenous Versus Heterogeneous Populations. PLoS One, 26;5(3):e9903, 2010.

  141. Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, and Suh Y. Evolution in Health and Medicine Sackler Colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. PNAS, 107(1):1710-1717, 2010.

  142. Sebastiani P, Montano M, Puca A, Timofeev N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SEJ, Anderson S, Hartley S, Sedgewick A, Arai Yasumichi, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Steinberg MH,  Hirose N, Atzmon G, Ruvkun G, Baldwin CT & Perls TT. RNA Editing Genes Associated with Extreme Old Age in Humans and Lifespan in C. elegans. PLoS One, 4 (12): e8210, 2009.

  143. Atzmon G, Barzilai N, Surks MI, Gabriely l. Genetic Predisposition to Elevated Serum Thyrotropin is Associated with Exceptional Longevity. JCEM, 94(12):4768-75, 2009.

  144. Pawlikowska L, Hu Donglei, Huntsman S, Sung A, Chu C, Chen J, Reiner A, Atzmon G, Barzilai N, Psaty B, Hsueh W-C, Cummings S, Browner W, Kwok P-Y, Ziv E. Association of common genetic variation in the IGF1 signaling pathway with human lifespan. Aging cell, 8(4):460-72, 2009.

  145. Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. Humanin: a novel central regulator of peripheral insulin action. PLoS one, 4(7):e6334, 2009.

  146. Walston JD, Matteini AM, Nievergelt C, Fallin DM, Barzilai N, Ziv E, Pawlikowska L, Kwok P, Cummings SR, Kooperberg C, LaCroix A, Russell PT, Atzmon G, Lange EM, Reiner AP. Inflammation and Stress-Related Candidate Genes, Plasmainterleukin-6 Levels, and Longevity In Older Adults. Experimental Gerontology, 44(5):350-5, 2009.

  147. Atzmon G, Barzilai N, Hollowell JG, Surks MI, Gabriely I. Extreme Longevity is Associated with Increased Serum Thyrotropin. JCEM, 94(4):1251-4, 2009.

  148. Shlush LI, Atzmon G, Weisshof R, Behar D, Yudkovsky G, Barzilai N, Skorecki K.  Ashkenazi Jewish Centenarians do not Demonstrate Enrichment in Mitochondrial Haplogroup J. PLoS One. 3(10):e3425, 2008.

  149. Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith SW, Barzilai N. Visceral Adipose Tissue Modulates Mammalian Longevity. Aging Cell. 7(3):438-40, 2008.

  150. Einstein FH, Bauman J, Fishman S, Thompson R, Atzmon G, Barzilai N, Muzumdar RH. Enhanced Activation of ‘Nutrient-Sensing pathway’ with Age Contributes to the Insulin Resistance and Inflammatory State. FASEB. 22(10):3450-7, 2008.

  151. Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, Scherer PE, Rincon M, Siegel G, Katz M, Lipton RB, Shuldiner AR, Barzilai N. Adiponectin levels and genotype: A potential regulator of life-span in humans. J Gerontol A Biol Sci Med Sci. 63(5):447-53, 2008.

  152. Atzmon G, Blum S, Feldman M, Cahaner A, Lavi U, Hillel J. QTLs detected in a multigenerational resource chicken population. Journal of Heredity. 99(5):528-38, 2008.

  153. Suh Y, Atzmon G, Cho M, Hwang D, Liu B, Leahy D, Barzilai N, Cohen P. Functionally significant insulin-like growth factor I receptor mutations in centenarians. PNAS. 105(9):3438-42, 2008.

  154. Einstein FH, Fishman S, Muzumdar R, Yang X, Atzmon G, Barzilai N. Accretion of Visceral Fat and Hepatic Insulin Resistance in Pregnant Rats. Am J Physiol Endocrinol Metab. 294(2):E451-5, 2008.

  155. Iwata N, Zhang J, Atzmon G, Leanza S, Cho J, Chomyn A, Burk RD, Barzilai N, Attardi G. Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians. Mitochondrion 7(4):267-72, 2007.

  156. Atzmon G, Blum S, Feldman M, Lavi U, Hillel J. Detection of agriculturally important QTLs in chickens and identification of the best genotyping strategy. Cytogenet Genome Res 117:327–337, 2007.

  157. Fishman S, Muzumdar R, Atzmon G, Ma X, Barzilai N. Resistance to Leptin Action is the Major Determinant of Hepatic Triglycerides Accumulation in vivo. FASEB 21(1):53-60, 2007.

  158. Bergman A, Atzmon G, Ye K, Barzilai N: Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Computational Biology, 3(8):e170, 2007.

  159. Atzmon G, Rincon M, Schechter C, Shuldiner A, Lipton R, Bergman A, Barzilai N: Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biology 4(4):e113, 2006.

  160. Atzmon G, Ronin YI, Korol A, Yonash N, Cheng H and Hillel J. QTLs associated with growth traits and abdominal fat weight and their interactions with gender and hatch in commercial meat-type chickens. Animal Genetics 37:352–358, 2006.

  161. Lahav T, Atzmon G, Blum S, Ben-Ari G, Weigend S, Cahaner A, Lavi U, Hillel J. Marker Assisted Selection Based On Multi-Trait Economic Index In Chicken: Experimental Results And Simulation. Animal Genetics 37: 482–488, 2006.

  162. Muzumdar R, Ma X, Fishman S, Yang X, Atzmon G, Vuguin P, Einstein FH, Hwang D, Cohen P, Barzilai N. Central and Opposing effects of IGF-1 and IGFBP-3 on systemic insulin action. Diabetes 55:2788-96, 2006.

  163. Terry DF, Diego FW, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL,  Wilcox MA, Farrer LA, Perls TT, Barzilai N, Baldwin CT, Asea A, Serum Heat Shock Protein 70 Level as a Biomarker of Exceptional Longevity. Mechanisms of Aging and Dev. 127(11):862-8, 2006.

  164. Barzilai N, Atzmon G, Derby CA, Bauman JM, Lipton RB, A Genotype of Exceptional Longevity is Associated with Preservation of Cognitive Function. Neurology 26;67(12):2170-5, 2006.

  165. Muzumdar RH, Ma X, Yang X, Atzmon G, Barzilai N: Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging. Neurobiol Aging, 27:9:1308-1314, 2006.

  166. Atzmon G, Einstein FH, Yang XM, Ma XH, Rincon M, Rudin E, Muzumdar R, Barzilai N: Differential responses of visceral and subcutaneous fat depots to nutrients. Diabetes 54:672-678, 2005.

  167. Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC: Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 96:412-418, 2005.

  168. Atzmon G, Rincon M, Rabizadeh P, Barzilai N: Biological evidence for inheritance of exceptional longevity. Mech Ageing Dev 126:341-345, 2005.

  169. Rincon M, Muzumdar R, Atzmon G, Barzilai N: The paradox of the insulin/IGF-1 signaling pathway in longevity. Mech Ageing Dev 125:397-403, 2004.

  170. Muzumdar R, Ma X, Atzmon G, Vuguin P, Yang X, Barzilai N: Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action. Diabetes 53:441-446, 2004.

  171. Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N: Clinical phenotype of families with longevity. JAGS 52:274-277, 2004.

  172. Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR: Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 290:2030-40, 2003.

  173. Muzumdar R, Ma X, Yang X, Atzmon G, Bernstein J, Karkanias G, Barzilai N: Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J 17:1130-1132, 2003.

  174. Ma X, Muzmudar R, Gabriely I, Atzmon G, Barzilai N. Does the brain lead the metabolic decline in aging?: Lessons from animal models and human centenarians. Clinical Neuroscience Research.  2(5-6): 269-362, 2003.

  175. Atzmon G, Yang XM, Muzumdar R, Ma XH, Gabriely I, Barzilai N: Differential gene expression between visceral and subcutaneous fat depots. Horm Metab Res 34:622-628, 2002.

  176. Atzmon G, Gabriely I, Greiner W, Davidson D, Schechter C, Barzilai N: Plasma HDL levels highly correlate with cognitive function in exceptional longevity. J Gerontol A Biol Sci Med Sci 57:M712-715, 2002.

  177. Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N: Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51:2951-2958, 2002.

  178. Atzmon G, Cassuto D, Lavi U, Cahaner A, Zeitlin G, Hillel J: DNA markers and crossbreeding scheme as means to select sires for heterosis in egg production of chickens. Anim Genet, 33:132-9, 2002.

  179. Atzmon G, Van Oss H, Cxosnek H: PCR-amplification of tomato yellow leaf curl virus (TYLCV) DNA from squashes of plants and whitefly vectors: application to the study of TYLCV acquisition and transmission. European Journal of Plant Pathology 104:189-194, 1998.

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